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• Activity deltas table
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Motif ID: FOX{D1,D2}.p2

Z-value: 1.094

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_+_116455898	2.413	NM_152367	MAB21L3	mab-21-like 3 (C. elegans)
chr3_-_71376919	2.196		FOXP1	forkhead box P1
chr2_-_192420168	1.675	NM_004657	SDPR	serum deprivation response
chr1_-_159459814	1.621		APOA2	apolipoprotein A-II
chr2_-_233586164	1.556	NM_019850	NGEF	neuronal guanine nucleotide exchange factor
chr4_-_152368492	1.522		SH3D19	SH3 domain containing 19
chr2_-_192419896	1.337		SDPR	serum deprivation response
chr10_+_123912930	1.331		TACC2	transforming, acidic coiled-coil containing protein 2
chr10_+_123913094	1.274	NM_006997 NM_206860	TACC2	transforming, acidic coiled-coil containing protein 2
chr17_-_61655915	1.268	NM_000042	APOH	apolipoprotein H (beta-2-glycoprotein I)
chr13_+_112825113	1.238	NM_000504	F10	coagulation factor X
chr3_-_126088530	1.233		ITGB5	integrin, beta 5
chr5_-_16795336	1.210		MYO10	myosin X
chr2_-_233586145	1.201		NGEF	neuronal guanine nucleotide exchange factor
chr3_-_71262426	1.198		FOXP1	forkhead box P1
chr2_-_165133239	1.197		GRB14	growth factor receptor-bound protein 14
chr7_+_134114912	1.196		CALD1	caldesmon 1
chr3_+_189413414	1.179	NM_005578	LPP	LIM domain containing preferred translocation partner in lipoma
chr10_-_52315390	1.070		A1CF	APOBEC1 complementation factor
chr10_+_63478974	1.067		ARID5B	AT rich interactive domain 5B (MRF1-like)
chr16_+_52027020	1.040		RBL2	retinoblastoma-like 2 (p130)
chr3_-_71262405	1.022		FOXP1	forkhead box P1
chr20_+_21054623	1.022	NM_001163022 NM_001163023 NM_018474	PLK1S1	polo-like kinase 1 substrate 1
chr11_-_114880275	1.013	NM_001098517 NM_014333	CADM1	cell adhesion molecule 1
chr14_+_22136968	1.011	NM_022060	ABHD4	abhydrolase domain containing 4
chr10_-_101831579	1.005	NM_001308	CPN1	carboxypeptidase N, polypeptide 1
chr10_-_44794146	1.005	NM_007021	C10orf10	chromosome 10 open reading frame 10
chr20_-_42561725	0.999
chr7_+_134114701	0.987	NM_004342 NM_033138 NM_033157	CALD1	caldesmon 1
chr12_+_119900677	0.986		HNF1A	HNF1 homeobox A
chr15_+_97009194	0.977		IGF1R	insulin-like growth factor 1 receptor
chr7_+_134114957	0.976		CALD1	caldesmon 1
chr1_+_227506751	0.968	NM_006542	SPHAR	S-phase response (cyclin related)
chr17_+_56109940	0.945	NM_001099432 NM_017679	BCAS3	breast carcinoma amplified sequence 3
chr1_-_12599934	0.936	NM_004753	DHRS3	dehydrogenase/reductase (SDR family) member 3
chr4_-_141294682	0.935	NM_018717	MAML3	mastermind-like 3 (Drosophila)
chr12_-_9159707	0.926		A2M	alpha-2-macroglobulin
chr14_+_23654307	0.926	NM_181357	DCAF11	DDB1 and CUL4 associated factor 11
chr12_-_9159742	0.924		A2M	alpha-2-macroglobulin
chr19_+_12995782	0.919		NFIX	nuclear factor I/X (CCAAT-binding transcription factor)
chr10_+_24795446	0.911		KIAA1217	KIAA1217
chr15_-_68781662	0.907	NM_001008224	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats
chrX_-_6156655	0.890	NM_181332	NLGN4X	neuroligin 4, X-linked
chr12_+_99391870	0.887		NR1H4	nuclear receptor subfamily 1, group H, member 4
chr3_-_58497913	0.884	NM_003500	ACOX2	acyl-CoA oxidase 2, branched chain
chr7_+_134483305	0.878	NM_018295	TMEM140	transmembrane protein 140
chr12_-_9159780	0.877		A2M	alpha-2-macroglobulin
chr14_+_23654161	0.875		DCAF11	DDB1 and CUL4 associated factor 11
chr16_+_54070302	0.861	NM_004530	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr12_+_119900931	0.861	NM_000545	HNF1A	HNF1 homeobox A
chr11_-_17147863	0.856	NM_002645	PIK3C2A	phosphoinositide-3-kinase, class 2, alpha polypeptide
chr15_+_22781292	0.856		PAR5	Prader-Willi/Angelman syndrome-5
chr4_+_120167264	0.854		SYNPO2	synaptopodin 2
chr3_-_71196696	0.850		FOXP1	forkhead box P1
chr10_+_24795465	0.850		KIAA1217	KIAA1217
chr1_-_60164912	0.844	NM_000775	CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2
chr17_+_69939130	0.844	NM_022036	GPRC5C	G protein-coupled receptor, family C, group 5, member C
chr2_-_133895795	0.837		NCKAP5	NCK-associated protein 5
chr1_-_159459999	0.835	NM_001643	APOA2	apolipoprotein A-II
chrX_-_6155887	0.831	NM_020742	NLGN4X	neuroligin 4, X-linked
chr6_+_127006298	0.830		LOC728666	PRELI domain containing 1 pseudogene
chr6_-_56824371	0.826		DST	dystonin
chr14_-_73620826	0.819		ALDH6A1	aldehyde dehydrogenase 6 family, member A1
chr12_+_12656109	0.815		CREBL2	cAMP responsive element binding protein-like 2
chr12_+_12656022	0.814	NM_001310	CREBL2	cAMP responsive element binding protein-like 2
chr11_+_101488380	0.812	NM_001195045	YAP1	Yes-associated protein 1
chr14_-_20563722	0.810	NM_016250 NM_201535 NM_201536 NM_201537	NDRG2	NDRG family member 2
chr2_-_97775300	0.803		TMEM131	transmembrane protein 131
chr2_-_188086612	0.799		TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr12_+_99391681	0.794	NM_005123	NR1H4	nuclear receptor subfamily 1, group H, member 4
chr14_-_20563698	0.786		NDRG2	NDRG family member 2
chr12_+_32578513	0.779		FGD4	FYVE, RhoGEF and PH domain containing 4
chr2_-_65447370	0.779	NM_001128210	SPRED2	sprouty-related, EVH1 domain containing 2
chr7_+_94377145	0.774	NM_001166161 NM_001166162 NM_001166163	PPP1R9A	protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr5_-_42847716	0.762	NM_001085486 NM_001093726 NM_005410	SEPP1	selenoprotein P, plasma, 1
chr5_+_78568094	0.760
chr20_+_2030527	0.756	NM_080836	STK35	serine/threonine kinase 35
chr13_-_98708549	0.752	NM_001098200 NM_005292	GPR18	G protein-coupled receptor 18
chr9_-_93163965	0.751		AUH	AU RNA binding protein/enoyl-CoA hydratase
chr12_+_105220638	0.750	NM_152772	TCP11L2	t-complex 11 (mouse)-like 2
chr10_-_92671005	0.743	NM_014391	ANKRD1	ankyrin repeat domain 1 (cardiac muscle)
chr14_+_23653745	0.742	NM_001163484	DCAF11	DDB1 and CUL4 associated factor 11
chr10_+_63331018	0.741	NM_032199	ARID5B	AT rich interactive domain 5B (MRF1-like)
chr2_-_65447267	0.736		SPRED2	sprouty-related, EVH1 domain containing 2
chr12_+_13240868	0.735	NM_001423	EMP1	epithelial membrane protein 1
chr7_-_87180499	0.734	NM_000927	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr2_-_174968595	0.730	NM_004882	CIR1	corepressor interacting with RBPJ, 1
chr14_+_23653848	0.729		DCAF11	DDB1 and CUL4 associated factor 11
chr12_-_9159789	0.723	NM_000014	A2M	alpha-2-macroglobulin
chr19_-_7244876	0.721	NM_000208 NM_001079817	INSR	insulin receptor
chr10_+_111959978	0.721	NM_001008541	MXI1	MAX interactor 1
chr10_-_52315436	0.717	NM_001198818 NM_001198819 NM_001198820 NM_014576 NM_138932 NM_138933	A1CF	APOBEC1 complementation factor
chr1_-_24342158	0.717	NM_021258	IL22RA1	interleukin 22 receptor, alpha 1
chr17_+_2627099	0.710		RAP1GAP2	RAP1 GTPase activating protein 2
chr12_+_13240987	0.692		EMP1	epithelial membrane protein 1
chr6_-_109521969	0.690	NM_014454	SESN1	sestrin 1
chr9_-_88087192	0.688	NM_030940	ISCA1	iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
chr3_-_187309442	0.683	NM_004454	ETV5	ets variant 5
chr8_-_119192985	0.681	NM_000127	EXT1	exostosin 1
chr3_-_150903749	0.677	NM_001168278	WWTR1	WW domain containing transcription regulator 1
chr14_+_23653819	0.677	NM_025230	DCAF11	DDB1 and CUL4 associated factor 11
chr1_-_92124064	0.677		TGFBR3	transforming growth factor, beta receptor III
chr20_+_2792688	0.676	NM_002836	PTPRA VPS16	protein tyrosine phosphatase, receptor type, A vacuolar protein sorting 16 homolog (S. cerevisiae)
chr20_-_42584100	0.675	NM_006811 NM_198941	SERINC3	serine incorporator 3
chr6_+_139136349	0.672	NM_015439	CCDC28A	coiled-coil domain containing 28A
chr4_-_111339201	0.672	NM_001130721 NM_024090	ELOVL6	ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr5_-_142045770	0.672	NM_000800	FGF1	fibroblast growth factor 1 (acidic)
chr19_+_46416975	0.666		AXL	AXL receptor tyrosine kinase
chr16_-_56389176	0.666	NM_001130099	KIFC3	kinesin family member C3
chr19_+_46416971	0.665		AXL	AXL receptor tyrosine kinase
chr1_+_33494745	0.663	NM_152493	ZNF362	zinc finger protein 362
chr17_+_35472566	0.661	NM_001190918 NM_003250 NM_199334	THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr19_+_46417099	0.660		AXL	AXL receptor tyrosine kinase
chr19_+_1158129	0.660		EFNA2	ephrin-A2
chr13_-_40138607	0.654	NM_002015	FOXO1	forkhead box O1
chr9_-_93164015	0.653	NM_001698	AUH	AU RNA binding protein/enoyl-CoA hydratase
chr17_+_38916895	0.651		DHX8	DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr17_-_6958695	0.648		ASGR2	asialoglycoprotein receptor 2
chr15_-_75135496	0.645		TSPAN3	tetraspanin 3
chr20_-_33705244	0.643	NM_003915	CPNE1	copine I
chr10_+_111975618	0.642	NM_005962	MXI1	MAX interactor 1
chr3_-_12916547	0.632		IQSEC1	IQ motif and Sec7 domain 1
chr18_-_53438854	0.629
chr5_-_142046175	0.628	NM_033136	FGF1	fibroblast growth factor 1 (acidic)
chr11_+_20005704	0.627		NAV2	neuron navigator 2
chr12_-_110410730	0.619		ATXN2	ataxin 2
chr2_-_188127294	0.619		TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_+_116151411	0.618		MET	met proto-oncogene (hepatocyte growth factor receptor)
chr3_-_95175282	0.617		PROS1	protein S (alpha)
chr2_-_188127430	0.616	NM_001032281 NM_006287	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_+_101680594	0.615	NM_004834 NM_145686 NM_145687	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4
chr4_+_124537334	0.613	NM_199327	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr17_+_54763689	0.611	NM_001005404	YPEL2	yippee-like 2 (Drosophila)
chr9_-_14900992	0.608	NM_144966	FREM1	FRAS1 related extracellular matrix 1
chr2_+_198089036	0.603		MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)
chr1_-_60165049	0.602		CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2
chr15_-_68128924	0.596		TLE3	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr20_-_45410033	0.594		ZMYND8	zinc finger, MYND-type containing 8
chr8_+_31616809	0.593	NM_013962	NRG1	neuregulin 1
chr14_-_73620912	0.592	NM_005589	ALDH6A1	aldehyde dehydrogenase 6 family, member A1
chr1_+_149877955	0.592		SNX27	sorting nexin family member 27
chr14_-_34414603	0.591	NM_013448 NM_182648	BAZ1A	bromodomain adjacent to zinc finger domain, 1A
chr21_-_34820916	0.581	NM_203418	RCAN1	regulator of calcineurin 1
chr10_-_92670764	0.578		ANKRD1	ankyrin repeat domain 1 (cardiac muscle)
chr13_-_109600709	0.576		COL4A1	collagen, type IV, alpha 1
chr5_+_86712376	0.573
chr9_-_134809774	0.573		TSC1	tuberous sclerosis 1
chr6_+_64414389	0.573	NM_015153	PHF3	PHD finger protein 3
chr8_-_134378630	0.572	NM_001135242 NM_006096	NDRG1	N-myc downstream regulated 1
chr6_+_155579788	0.571	NM_001010927	TIAM2	T-cell lymphoma invasion and metastasis 2
chr10_-_54201400	0.568	NM_000242	MBL2	mannose-binding lectin (protein C) 2, soluble
chr2_+_111594921	0.567	NM_006538 NM_138621 NM_207002	BCL2L11	BCL2-like 11 (apoptosis facilitator)
chr2_-_160181206	0.565	NM_013450	BAZ2B	bromodomain adjacent to zinc finger domain, 2B
chr11_-_62070775	0.564		AHNAK	AHNAK nucleoprotein
chr2_+_86800940	0.563		RMND5A	required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr6_-_56824672	0.558		DST	dystonin
chr2_+_86800898	0.558	NM_022780	RMND5A	required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr12_+_13240983	0.555		EMP1	epithelial membrane protein 1
chr17_+_38247493	0.555		PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr17_+_38916758	0.554	NM_004941	DHX8	DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr16_-_30014993	0.553	NM_031477 NM_001145524	YPEL3	yippee-like 3 (Drosophila)
chr20_-_33783409	0.551		RBM39	RNA binding motif protein 39
chr2_-_87156616	0.545		LOC285074	anaphase promoting complex subunit 1 pseudogene
chr2_-_180319013	0.544	NM_001113397	ZNF385B	zinc finger protein 385B
chr2_-_165259334	0.544		COBLL1	COBL-like 1
chr2_+_86801081	0.543		RMND5A	required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr7_-_50596238	0.537	NM_000790	DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr15_+_22832198	0.531		SNRPN	small nuclear ribonucleoprotein polypeptide N
chr20_+_2031418	0.531		STK35	serine/threonine kinase 35
chr10_+_102782156	0.530		SFXN3	sideroflexin 3
chr10_+_123738678	0.528	NM_206861 NM_206862	TACC2	transforming, acidic coiled-coil containing protein 2
chr16_+_82540172	0.526	NM_013370 NM_182980	OSGIN1	oxidative stress induced growth inhibitor 1
chr3_-_79899748	0.522	NM_002941	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr12_-_74711642	0.519	NM_007350	PHLDA1	pleckstrin homology-like domain, family A, member 1
chr1_-_167822248	0.515		F5	coagulation factor V (proaccelerin, labile factor)
chr11_-_46572160	0.509		AMBRA1	autophagy/beclin-1 regulator 1
chr15_+_78520634	0.508		ARNT2	aryl-hydrocarbon receptor nuclear translocator 2
chr16_+_24709922	0.507		TNRC6A	trinucleotide repeat containing 6A
chr6_+_32230172	0.505		PPT2	palmitoyl-protein thioesterase 2
chr15_-_58671929	0.500	NM_134262	RORA	RAR-related orphan receptor A
chr10_+_31650069	0.497	NM_001128128 NM_001174094	ZEB1	zinc finger E-box binding homeobox 1
chr9_-_134809816	0.497	NM_000368 NM_001162426 NM_001162427	TSC1	tuberous sclerosis 1
chr1_+_109043550	0.495		PRPF38B	PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr17_-_62671738	0.493		HELZ	helicase with zinc finger
chr5_+_72287630	0.493		FCHO2	FCH domain only 2
chr2_-_20375497	0.491		PUM2	pumilio homolog 2 (Drosophila)
chr14_-_93859394	0.491	NM_001756	SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr10_-_118670968	0.489		KIAA1598	KIAA1598
chr2_+_11591692	0.485	NM_014668	GREB1	growth regulation by estrogen in breast cancer 1
chr16_-_46957254	0.481		SIAH1	seven in absentia homolog 1 (Drosophila)
chr20_+_35266581	0.480		RPN2	ribophorin II
chr3_+_23961739	0.477	NM_005126	NR1D2	nuclear receptor subfamily 1, group D, member 2
chr9_+_117955890	0.474	NM_002581	PAPPA	pregnancy-associated plasma protein A, pappalysin 1
chr1_-_167822334	0.472	NM_000130	F5	coagulation factor V (proaccelerin, labile factor)
chr11_+_22652957	0.470		GAS2	growth arrest-specific 2
chr4_+_140806371	0.467	NM_002413	MGST2	microsomal glutathione S-transferase 2
chr3_+_38322430	0.462	NM_004803	SLC22A14	solute carrier family 22, member 14
chr11_+_73037382	0.461	NM_001130036	PLEKHB1	pleckstrin homology domain containing, family B (evectins) member 1
chr17_-_36719030	0.460	NM_001146182	KRTAP16-1	keratin associated protein 16-1
chr1_-_27113018	0.459	NM_021969	NR0B2	nuclear receptor subfamily 0, group B, member 2

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.46	1.33e-04	GO:0048519	negative regulation of biological process
1.95	1.92e-04	GO:0007167	enzyme linked receptor protein signaling pathway
1.46	4.13e-04	GO:0048523	negative regulation of cellular process
1.72	5.07e-04	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.18	1.77e-03	GO:0065007	biological regulation
1.96	3.28e-03	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
1.83	4.01e-03	GO:0010558	negative regulation of macromolecule biosynthetic process
1.19	6.86e-03	GO:0050794	regulation of cellular process
1.18	7.12e-03	GO:0050789	regulation of biological process
1.83	7.23e-03	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.77	8.80e-03	GO:0009890	negative regulation of biosynthetic process
1.83	1.03e-02	GO:0010629	negative regulation of gene expression
1.65	1.24e-02	GO:0010605	negative regulation of macromolecule metabolic process
1.62	1.43e-02	GO:0009892	negative regulation of metabolic process
2.06	1.56e-02	GO:0043009	chordate embryonic development
1.76	1.64e-02	GO:0031327	negative regulation of cellular biosynthetic process
1.85	1.73e-02	GO:0051253	negative regulation of RNA metabolic process
1.86	1.94e-02	GO:0045892	negative regulation of transcription, DNA-dependent
2.03	2.10e-02	GO:0009792	embryo development ending in birth or egg hatching
1.11	2.49e-02	GO:0009987	cellular process
1.63	2.54e-02	GO:0031324	negative regulation of cellular metabolic process
1.78	3.06e-02	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35	3.86e-02	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.28	3.88e-02	GO:0080090	regulation of primary metabolic process
1.29	3.92e-02	GO:0060255	regulation of macromolecule metabolic process
1.34	3.94e-02	GO:0010556	regulation of macromolecule biosynthetic process
1.28	4.13e-02	GO:0016043	cellular component organization
1.72	4.40e-02	GO:0009719	response to endogenous stimulus
1.75	4.48e-02	GO:0051172	negative regulation of nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.13	1.44e-06	GO:0005622	intracellular
1.13	2.05e-06	GO:0044424	intracellular part
1.16	9.12e-06	GO:0043226	organelle
1.15	1.91e-05	GO:0043229	intracellular organelle
1.25	2.75e-05	GO:0005634	nucleus
1.17	3.11e-05	GO:0043227	membrane-bounded organelle
1.16	5.13e-05	GO:0043231	intracellular membrane-bounded organelle
1.20	7.67e-03	GO:0044422	organelle part
1.19	1.07e-02	GO:0044446	intracellular organelle part
1.33	3.14e-02	GO:0044428	nuclear part
1.31	4.81e-02	GO:0043233	organelle lumen

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.26	9.72e-10	GO:0005515	protein binding
1.12	3.21e-05	GO:0005488	binding
1.87	4.31e-02	GO:0003712	transcription cofactor activity
1.87	4.59e-02	GO:0000988	protein binding transcription factor activity
1.87	4.59e-02	GO:0000989	transcription factor binding transcription factor activity