Motif ID: FOX{D1,D2}.p2

Z-value: 1.094


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD2chr1_+_47674275-0.774.3e-04Click!
FOXD1chr5_-_72779585-0.224.0e-01Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_116455898 2.413 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr3_-_71376919 2.196 FOXP1
forkhead box P1
chr2_-_192420168 1.675 NM_004657
SDPR
serum deprivation response
chr1_-_159459814 1.621 APOA2
apolipoprotein A-II
chr2_-_233586164 1.556 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr4_-_152368492 1.522 SH3D19
SH3 domain containing 19
chr2_-_192419896 1.337 SDPR
serum deprivation response
chr10_+_123912930 1.331 TACC2
transforming, acidic coiled-coil containing protein 2
chr10_+_123913094 1.274 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr17_-_61655915 1.268 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr13_+_112825113 1.238 NM_000504
F10
coagulation factor X
chr3_-_126088530 1.233 ITGB5
integrin, beta 5
chr5_-_16795336 1.210 MYO10
myosin X
chr2_-_233586145 1.201 NGEF
neuronal guanine nucleotide exchange factor
chr3_-_71262426 1.198 FOXP1
forkhead box P1
chr2_-_165133239 1.197 GRB14
growth factor receptor-bound protein 14
chr7_+_134114912 1.196 CALD1
caldesmon 1
chr3_+_189413414 1.179 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_-_52315390 1.070 A1CF
APOBEC1 complementation factor
chr10_+_63478974 1.067 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr16_+_52027020 1.040 RBL2
retinoblastoma-like 2 (p130)
chr3_-_71262405 1.022 FOXP1
forkhead box P1
chr20_+_21054623 1.022 NM_001163022
NM_001163023
NM_018474
PLK1S1


polo-like kinase 1 substrate 1


chr11_-_114880275 1.013 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr14_+_22136968 1.011 NM_022060
ABHD4
abhydrolase domain containing 4
chr10_-_101831579 1.005 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr10_-_44794146 1.005 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr20_-_42561725 0.999


chr7_+_134114701 0.987 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr12_+_119900677 0.986 HNF1A
HNF1 homeobox A
chr15_+_97009194 0.977 IGF1R
insulin-like growth factor 1 receptor
chr7_+_134114957 0.976 CALD1
caldesmon 1
chr1_+_227506751 0.968 NM_006542
SPHAR
S-phase response (cyclin related)
chr17_+_56109940 0.945 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr1_-_12599934 0.936 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr4_-_141294682 0.935 NM_018717
MAML3
mastermind-like 3 (Drosophila)
chr12_-_9159707 0.926 A2M
alpha-2-macroglobulin
chr14_+_23654307 0.926 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr12_-_9159742 0.924 A2M
alpha-2-macroglobulin
chr19_+_12995782 0.919 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr10_+_24795446 0.911 KIAA1217
KIAA1217
chr15_-_68781662 0.907 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chrX_-_6156655 0.890 NM_181332
NLGN4X
neuroligin 4, X-linked
chr12_+_99391870 0.887 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr3_-_58497913 0.884 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr7_+_134483305 0.878 NM_018295
TMEM140
transmembrane protein 140
chr12_-_9159780 0.877 A2M
alpha-2-macroglobulin
chr14_+_23654161 0.875 DCAF11
DDB1 and CUL4 associated factor 11
chr16_+_54070302 0.861 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr12_+_119900931 0.861 NM_000545
HNF1A
HNF1 homeobox A
chr11_-_17147863 0.856 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr15_+_22781292 0.856 PAR5
Prader-Willi/Angelman syndrome-5
chr4_+_120167264 0.854 SYNPO2
synaptopodin 2
chr3_-_71196696 0.850 FOXP1
forkhead box P1
chr10_+_24795465 0.850 KIAA1217
KIAA1217
chr1_-_60164912 0.844 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr17_+_69939130 0.844 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr2_-_133895795 0.837 NCKAP5
NCK-associated protein 5
chr1_-_159459999 0.835 NM_001643
APOA2
apolipoprotein A-II
chrX_-_6155887 0.831 NM_020742
NLGN4X
neuroligin 4, X-linked
chr6_+_127006298 0.830 LOC728666
PRELI domain containing 1 pseudogene
chr6_-_56824371 0.826 DST
dystonin
chr14_-_73620826 0.819 ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr12_+_12656109 0.815 CREBL2
cAMP responsive element binding protein-like 2
chr12_+_12656022 0.814 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr11_+_101488380 0.812 NM_001195045
YAP1
Yes-associated protein 1
chr14_-_20563722 0.810 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr2_-_97775300 0.803 TMEM131
transmembrane protein 131
chr2_-_188086612 0.799 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr12_+_99391681 0.794 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr14_-_20563698 0.786 NDRG2
NDRG family member 2
chr12_+_32578513 0.779 FGD4
FYVE, RhoGEF and PH domain containing 4
chr2_-_65447370 0.779 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr7_+_94377145 0.774 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr5_-_42847716 0.762 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr5_+_78568094 0.760


chr20_+_2030527 0.756 NM_080836
STK35
serine/threonine kinase 35
chr13_-_98708549 0.752 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr9_-_93163965 0.751 AUH
AU RNA binding protein/enoyl-CoA hydratase
chr12_+_105220638 0.750 NM_152772
TCP11L2
t-complex 11 (mouse)-like 2
chr10_-_92671005 0.743 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr14_+_23653745 0.742 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr10_+_63331018 0.741 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr2_-_65447267 0.736 SPRED2
sprouty-related, EVH1 domain containing 2
chr12_+_13240868 0.735 NM_001423
EMP1
epithelial membrane protein 1
chr7_-_87180499 0.734 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr2_-_174968595 0.730 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr14_+_23653848 0.729 DCAF11
DDB1 and CUL4 associated factor 11
chr12_-_9159789 0.723 NM_000014
A2M
alpha-2-macroglobulin
chr19_-_7244876 0.721 NM_000208
NM_001079817
INSR

insulin receptor

chr10_+_111959978 0.721 NM_001008541
MXI1
MAX interactor 1
chr10_-_52315436 0.717 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr1_-_24342158 0.717 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr17_+_2627099 0.710 RAP1GAP2
RAP1 GTPase activating protein 2
chr12_+_13240987 0.692 EMP1
epithelial membrane protein 1
chr6_-_109521969 0.690 NM_014454
SESN1
sestrin 1
chr9_-_88087192 0.688 NM_030940
ISCA1
iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
chr3_-_187309442 0.683 NM_004454
ETV5
ets variant 5
chr8_-_119192985 0.681 NM_000127
EXT1
exostosin 1
chr3_-_150903749 0.677 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr14_+_23653819 0.677 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr1_-_92124064 0.677 TGFBR3
transforming growth factor, beta receptor III
chr20_+_2792688 0.676 NM_002836
PTPRA
VPS16
protein tyrosine phosphatase, receptor type, A
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr20_-_42584100 0.675 NM_006811
NM_198941
SERINC3

serine incorporator 3

chr6_+_139136349 0.672 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr4_-_111339201 0.672 NM_001130721
NM_024090
ELOVL6

ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)

chr5_-_142045770 0.672 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr19_+_46416975 0.666 AXL
AXL receptor tyrosine kinase
chr16_-_56389176 0.666 NM_001130099
KIFC3
kinesin family member C3
chr19_+_46416971 0.665 AXL
AXL receptor tyrosine kinase
chr1_+_33494745 0.663 NM_152493
ZNF362
zinc finger protein 362
chr17_+_35472566 0.661 NM_001190918
NM_003250
NM_199334
THRA


thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)


chr19_+_46417099 0.660 AXL
AXL receptor tyrosine kinase
chr19_+_1158129 0.660 EFNA2
ephrin-A2
chr13_-_40138607 0.654 NM_002015
FOXO1
forkhead box O1
chr9_-_93164015 0.653 NM_001698
AUH
AU RNA binding protein/enoyl-CoA hydratase
chr17_+_38916895 0.651 DHX8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr17_-_6958695 0.648 ASGR2
asialoglycoprotein receptor 2
chr15_-_75135496 0.645 TSPAN3
tetraspanin 3
chr20_-_33705244 0.643 NM_003915
CPNE1
copine I
chr10_+_111975618 0.642 NM_005962
MXI1
MAX interactor 1
chr3_-_12916547 0.632 IQSEC1
IQ motif and Sec7 domain 1
chr18_-_53438854 0.629


chr5_-_142046175 0.628 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr11_+_20005704 0.627 NAV2
neuron navigator 2
chr12_-_110410730 0.619 ATXN2
ataxin 2
chr2_-_188127294 0.619 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_+_116151411 0.618 MET
met proto-oncogene (hepatocyte growth factor receptor)
chr3_-_95175282 0.617 PROS1
protein S (alpha)
chr2_-_188127430 0.616 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr2_+_101680594 0.615 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr4_+_124537334 0.613 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr17_+_54763689 0.611 NM_001005404
YPEL2
yippee-like 2 (Drosophila)
chr9_-_14900992 0.608 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr2_+_198089036 0.603 MOBKL3
MOB1, Mps One Binder kinase activator-like 3 (yeast)
chr1_-_60165049 0.602 CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr15_-_68128924 0.596 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr20_-_45410033 0.594 ZMYND8
zinc finger, MYND-type containing 8
chr8_+_31616809 0.593 NM_013962
NRG1
neuregulin 1
chr14_-_73620912 0.592 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr1_+_149877955 0.592 SNX27
sorting nexin family member 27
chr14_-_34414603 0.591 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr21_-_34820916 0.581 NM_203418
RCAN1
regulator of calcineurin 1
chr10_-_92670764 0.578 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr13_-_109600709 0.576 COL4A1
collagen, type IV, alpha 1
chr5_+_86712376 0.573


chr9_-_134809774 0.573 TSC1
tuberous sclerosis 1
chr6_+_64414389 0.573 NM_015153
PHF3
PHD finger protein 3
chr8_-_134378630 0.572 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr6_+_155579788 0.571 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr10_-_54201400 0.568 NM_000242
MBL2
mannose-binding lectin (protein C) 2, soluble
chr2_+_111594921 0.567 NM_006538
NM_138621
NM_207002
BCL2L11


BCL2-like 11 (apoptosis facilitator)


chr2_-_160181206 0.565 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr11_-_62070775 0.564 AHNAK
AHNAK nucleoprotein
chr2_+_86800940 0.563 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr6_-_56824672 0.558 DST
dystonin
chr2_+_86800898 0.558 NM_022780
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr12_+_13240983 0.555 EMP1
epithelial membrane protein 1
chr17_+_38247493 0.555 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr17_+_38916758 0.554 NM_004941
DHX8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr16_-_30014993 0.553 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr20_-_33783409 0.551 RBM39
RNA binding motif protein 39
chr2_-_87156616 0.545 LOC285074
anaphase promoting complex subunit 1 pseudogene
chr2_-_180319013 0.544 NM_001113397
ZNF385B
zinc finger protein 385B
chr2_-_165259334 0.544 COBLL1
COBL-like 1
chr2_+_86801081 0.543 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr7_-_50596238 0.537 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr15_+_22832198 0.531 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr20_+_2031418 0.531 STK35
serine/threonine kinase 35
chr10_+_102782156 0.530 SFXN3
sideroflexin 3
chr10_+_123738678 0.528 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr16_+_82540172 0.526 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr3_-_79899748 0.522 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr12_-_74711642 0.519 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr1_-_167822248 0.515 F5
coagulation factor V (proaccelerin, labile factor)
chr11_-_46572160 0.509 AMBRA1
autophagy/beclin-1 regulator 1
chr15_+_78520634 0.508 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr16_+_24709922 0.507 TNRC6A
trinucleotide repeat containing 6A
chr6_+_32230172 0.505 PPT2
palmitoyl-protein thioesterase 2
chr15_-_58671929 0.500 NM_134262
RORA
RAR-related orphan receptor A
chr10_+_31650069 0.497 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr9_-_134809816 0.497 NM_000368
NM_001162426
NM_001162427
TSC1


tuberous sclerosis 1


chr1_+_109043550 0.495 PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr17_-_62671738 0.493 HELZ
helicase with zinc finger
chr5_+_72287630 0.493 FCHO2
FCH domain only 2
chr2_-_20375497 0.491 PUM2
pumilio homolog 2 (Drosophila)
chr14_-_93859394 0.491 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr10_-_118670968 0.489 KIAA1598
KIAA1598
chr2_+_11591692 0.485 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr16_-_46957254 0.481 SIAH1
seven in absentia homolog 1 (Drosophila)
chr20_+_35266581 0.480 RPN2
ribophorin II
chr3_+_23961739 0.477 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr9_+_117955890 0.474 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr1_-_167822334 0.472 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr11_+_22652957 0.470 GAS2
growth arrest-specific 2
chr4_+_140806371 0.467 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr3_+_38322430 0.462 NM_004803
SLC22A14
solute carrier family 22, member 14
chr11_+_73037382 0.461 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr17_-_36719030 0.460 NM_001146182
KRTAP16-1
keratin associated protein 16-1
chr1_-_27113018 0.459 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 1.33e-04 GO:0048519 negative regulation of biological process
1.95 1.92e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.46 4.13e-04 GO:0048523 negative regulation of cellular process
1.72 5.07e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.18 1.77e-03 GO:0065007 biological regulation
1.96 3.28e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.83 4.01e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.19 6.86e-03 GO:0050794 regulation of cellular process
1.18 7.12e-03 GO:0050789 regulation of biological process
1.83 7.23e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.77 8.80e-03 GO:0009890 negative regulation of biosynthetic process
1.83 1.03e-02 GO:0010629 negative regulation of gene expression
1.65 1.24e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.62 1.43e-02 GO:0009892 negative regulation of metabolic process
2.06 1.56e-02 GO:0043009 chordate embryonic development
1.76 1.64e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.85 1.73e-02 GO:0051253 negative regulation of RNA metabolic process
1.86 1.94e-02 GO:0045892 negative regulation of transcription, DNA-dependent
2.03 2.10e-02 GO:0009792 embryo development ending in birth or egg hatching
1.11 2.49e-02 GO:0009987 cellular process
1.63 2.54e-02 GO:0031324 negative regulation of cellular metabolic process
1.78 3.06e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 3.86e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.28 3.88e-02 GO:0080090 regulation of primary metabolic process
1.29 3.92e-02 GO:0060255 regulation of macromolecule metabolic process
1.34 3.94e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.28 4.13e-02 GO:0016043 cellular component organization
1.72 4.40e-02 GO:0009719 response to endogenous stimulus
1.75 4.48e-02 GO:0051172 negative regulation of nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 1.44e-06 GO:0005622 intracellular
1.13 2.05e-06 GO:0044424 intracellular part
1.16 9.12e-06 GO:0043226 organelle
1.15 1.91e-05 GO:0043229 intracellular organelle
1.25 2.75e-05 GO:0005634 nucleus
1.17 3.11e-05 GO:0043227 membrane-bounded organelle
1.16 5.13e-05 GO:0043231 intracellular membrane-bounded organelle
1.20 7.67e-03 GO:0044422 organelle part
1.19 1.07e-02 GO:0044446 intracellular organelle part
1.33 3.14e-02 GO:0044428 nuclear part
1.31 4.81e-02 GO:0043233 organelle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.26 9.72e-10 GO:0005515 protein binding
1.12 3.21e-05 GO:0005488 binding
1.87 4.31e-02 GO:0003712 transcription cofactor activity
1.87 4.59e-02 GO:0000988 protein binding transcription factor activity
1.87 4.59e-02 GO:0000989 transcription factor binding transcription factor activity