Motif ID: FOX{D1,D2}.p2

Z-value: 1.094


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD2chr1_+_47674275-0.774.3e-04Click!
FOXD1chr5_-_72779585-0.224.0e-01Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_116455898 2.413 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr3_-_71376919 2.196 FOXP1
forkhead box P1
chr2_-_192420168 1.675 NM_004657
SDPR
serum deprivation response
chr1_-_159459814 1.621 APOA2
apolipoprotein A-II
chr2_-_233586164 1.556 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr4_-_152368492 1.522 SH3D19
SH3 domain containing 19
chr2_-_192419896 1.337 SDPR
serum deprivation response
chr10_+_123912930 1.331 TACC2
transforming, acidic coiled-coil containing protein 2
chr10_+_123913094 1.274 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr17_-_61655915 1.268 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr13_+_112825113 1.238 NM_000504
F10
coagulation factor X
chr3_-_126088530 1.233 ITGB5
integrin, beta 5
chr5_-_16795336 1.210 MYO10
myosin X
chr2_-_233586145 1.201 NGEF
neuronal guanine nucleotide exchange factor
chr3_-_71262426 1.198 FOXP1
forkhead box P1
chr2_-_165133239 1.197 GRB14
growth factor receptor-bound protein 14
chr7_+_134114912 1.196 CALD1
caldesmon 1
chr3_+_189413414 1.179 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_-_52315390 1.070 A1CF
APOBEC1 complementation factor
chr10_+_63478974 1.067 ARID5B
AT rich interactive domain 5B (MRF1-like)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
2.06 1.56e-02 GO:0043009 chordate embryonic development
2.03 2.10e-02 GO:0009792 embryo development ending in birth or egg hatching
1.96 3.28e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.95 1.92e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.86 1.94e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.85 1.73e-02 GO:0051253 negative regulation of RNA metabolic process
1.83 4.01e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.83 7.23e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.83 1.03e-02 GO:0010629 negative regulation of gene expression
1.78 3.06e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.77 8.80e-03 GO:0009890 negative regulation of biosynthetic process
1.76 1.64e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.75 4.48e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.72 5.07e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.72 4.40e-02 GO:0009719 response to endogenous stimulus
1.65 1.24e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.63 2.54e-02 GO:0031324 negative regulation of cellular metabolic process
1.62 1.43e-02 GO:0009892 negative regulation of metabolic process
1.46 1.33e-04 GO:0048519 negative regulation of biological process
1.46 4.13e-04 GO:0048523 negative regulation of cellular process

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.33 3.14e-02 GO:0044428 nuclear part
1.31 4.81e-02 GO:0043233 organelle lumen
1.25 2.75e-05 GO:0005634 nucleus
1.20 7.67e-03 GO:0044422 organelle part
1.19 1.07e-02 GO:0044446 intracellular organelle part
1.17 3.11e-05 GO:0043227 membrane-bounded organelle
1.16 9.12e-06 GO:0043226 organelle
1.16 5.13e-05 GO:0043231 intracellular membrane-bounded organelle
1.15 1.91e-05 GO:0043229 intracellular organelle
1.13 1.44e-06 GO:0005622 intracellular
1.13 2.05e-06 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.87 4.31e-02 GO:0003712 transcription cofactor activity
1.87 4.59e-02 GO:0000988 protein binding transcription factor activity
1.87 4.59e-02 GO:0000989 transcription factor binding transcription factor activity
1.26 9.72e-10 GO:0005515 protein binding
1.12 3.21e-05 GO:0005488 binding